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[Changes in the stimulation of mitochondrial respiration by adrenaline depending upon the dose].

М. Н. Кондрашова, A M Babskiĭ

Abstract

Effects of low and high 25 and 100 micrograms per 100 g of body weight doses of adrenaline on respiration and oxidative phosphorylation in rat liver mitochondria are compared. The high dose of adrenaline is shown to decrease activation of respiration and phosphorylation typical of the low doses. This decrease is caused by inhibition of succinate dehydrogenase and is accompanied by uncoupling of respiration and phosphorylation in mitochondria.

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Key concepts: Respiration, Oxidative phosphorylation, Mitochondrion, Stimulation, Phosphorylation, Succinate dehydrogenase, Chemistry, Endocrinology