[The discovery of JAK2 mutation has changed the diagnostic criteria of myeloproliferative neoplasms].
Ping Zhu
Abstract
Ping Zhu
Abstract
从2005年报道JAK2 V617F突变发生于慢性骨髓增殖性疾病(myeloproliferative disorder,MPD)[1-3]以来,这个基因突变的发现改变了MPD的分类和诊断.以往MPD包含慢性粒细胞白血病(CML),真性红细胞增多症(PV),原发性血小板增多症(ET),和原发性骨髓纤维化(PMF),慢性中性粒细胞白血病(CNL),慢性嗜酸细胞白血病/高嗜酸细胞综合征(CEL/HES)等多种疾病。
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从2005年报道JAK2 V617F突变发生于慢性骨髓增殖性疾病(myeloproliferative disorder,MPD)[1-3]以来,这个基因突变的发现改变了MPD的分类和诊断.以往MPD包含慢性粒细胞白血病(CML),真性红细胞增多症(PV),原发性血小板增多症(ET),和原发性骨髓纤维化(PMF),慢性中性粒细胞白血病(CNL),慢性嗜酸细胞白血病/高嗜酸细胞综合征(CEL/HES)等多种疾病。
Key concepts: Mutation, Myeloproliferative Disorders, Cancer research, Medicine, Internal medicine, Genetics, Biology, Gene