[Effect of imipramine-like antidepressants on head shaking induced by 5-hydroxytryptophan in mice].

In the reaction of head twitching (HT) in mice in response to 5-oxytryptophan administration in the capacity of a serotonergic model antidepressants chlorimipramine and imipramine and also chlorpheniramine (suprastin) expressed a serotonopositive action in doses of 1.0, 5,0, and 1.0 mg/kg, respectively. Quiprazine produced a serotonomimetic action. Desipramine exerted abmivalent activity in doses of 1.0--20.0 mg/kg, whereas iprindol and morphaphen were ineffective in doses up to 20.0 mg/kg. Amitriptyline, noveril, melitracene, trimipramine, and ludiomil inhibited HT in doses of from 0.5, 1.0, 20.0, 20.0, and 20.0 mg/kg, respectively. The results are discussed in the light of the concept on the complex "neurotransmitter activity" spectrum of imipramine-like antidepressants.