1989•PubMedRequires access

[Antitubercular agents. 45. Antimycobacterial thiohydrazide].

Karel Waisser, Z. ODLEROVA, N Houngbedji, Walter Thiel, Rudolf Mayer

Abstract

The present paper investigates the activity of thiohydrazides containing a structural fragment of oxalic acid against Mycobacterium tuberculosis and Mycobacterium kansasii. The drugs included heterocyclic compounds as well. All compounds under study show medium activity. The minimal inhibition concentrations against Mycobacterium kansasii are approximately 3 times higher than against Mycobacterium tuberculosis. The most effective aromatic compounds have the RM values (silica gel impregnated with silicon oil-water) in the interval of 2.2-2.6.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Antimycobacterial, Mycobacterium kansasii, Mycobacterium tuberculosis, Mycobacterium, Chemistry, Oxalic acid, Microbiology, Tuberculosis