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Cytotoxic lymphocytes in Hashimoto thyroiditis. An in vitro assay system using 51 Cr-labelled chicken red blood cells coated with thyroglobulin.

Calder Ba, WJ Penhale, Barnes Ew, Irvine Wj

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Abstract

An in vitro method is described to detect lymphocytes in patients with Hashimoto thyroiditis that are cytotoxic to thyroglobulin-coated chicken red blood cells. Using this technique, the cytotoxic index of lymphocytes from patients with Hashimoto thyroiditis was 25·46±3·81 (SEM), which is significantly different from that obtained with lymphocytes from control subjects, 6·28±0·80.

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What this paper is about

An in vitro method is described to detect lymphocytes in patients with Hashimoto thyroiditis that are cytotoxic to thyroglobulin-coated chicken red blood cells. Using this technique, the cytotoxic index of lymphocytes from patients with Hashimoto thyroiditis was 25·46±3·81 (SEM), which is significantly different from that obtained with lymphocytes from control subjects, 6·28±0·80.

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OpenAlex reports 42 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

An in vitro method is described to detect lymphocytes in patients with Hashimoto thyroiditis that are cytotoxic to thyroglobulin-coated chicken red blood cells. Using this technique, the cytotoxic index of lymphocytes from patients with Hashimoto thyroiditis was 25·46±3·81 (SEM), which is significantly different from that obtained with lymphocytes from control subjects, 6·28±0·80.

Key concepts: Thyroglobulin, Cytotoxic T cell, Thyroiditis, In vitro, Immunology, Thyroid, Medicine, Cytotoxicity

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Cytotoxic lymphocytes in Hashimoto thyroiditis. An in vitro assay system using 51 Cr-labelled chicken red blood cells coated with thyroglobulin. — Research Paper | ScholarLens