1983•PubMedRequires access
Influence of amphetamine on brown adipose thermogenesis.
Wellman Pj
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Abstract
Amphetamine (0.5, 1.0, 2.0 or 4.0 mg/kg) produced dose-dependent activation of interscapular brown-adipose tissue (IBAT) in female rats anesthetized with urethane (1.2 g/kg). Amphetamine-induced thermogenesis may reflect activation of beta-adrenergic receptors as evidenced by the rapid reversal of amphetamine-induced thermogenesis by propranolol (1.0 mg/kg). The potential relation of this effect to the anorexic property of amphetamine is discussed.