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[Subpopulations of T lymphocytes in bronchoalveolar lavage (BAL) fluid of different interstitial lung diseases].

Maria Chosia, Colette Marsan

Abstract

Immunocytochemical examinations using the PAP method with monoclonal antibodies against lymphocytes T (CD3, CD4, CD8) were carried out in 31 BAL's from patients with different interstitial lung diseases. A distinct increase of the CD4 (T "helper"): CD8 (T "suppressor") ratio was found in patients with sarcoidosis and in a patient with pigeon breeder's disease. A profound decrease of the CD4/CD8 ratio was found in HIV positive patients. The authors also discussed the methodological problems of correct typing of T cells in BAL.

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Key concepts: Medicine, Bronchoalveolar lavage, Sarcoidosis, Interstitial lung disease, CD8, Monoclonal antibody, Lung, CD3