ScholarLens Back to search
2008•PubMedRequires access

[Clinical and genetic features in patients with asthma and their relatives].

I I Cherkashina, Svetlana Yu. Nikulina, Logvinenko Ni, Maksimov Vn, Liberdovskaia Ed

Open publisher page 1 citations

Abstract

A familial survey was conducted in 81 probands who were diagnosed as having bronchial asthma (BA) and their 183 first-, second-, and third-degree relatives (a study group). A control group comprised 263 apparently healthy individuals. The familial accumulation of BA was ascertained in the families of probands with this condition. Autosomal dominant inheritance of BA was established. The heterozygous variant of the macrophage-colony-stimulating factor receptor (MCSFR) gene genotype chi-fms may be considered as one of the genetic predictors of BA. The homozygous genotype in a rare allele of the MCSFR gene may be also a predictor of BA.

About this research paper

What this paper is about

A familial survey was conducted in 81 probands who were diagnosed as having bronchial asthma (BA) and their 183 first-, second-, and third-degree relatives (a study group). A control group comprised 263 apparently healthy individuals. The familial accumulation of BA was ascertained in the families of probands with this condition. Autosomal dominant inheritance of BA was established. The heterozygous variant of the macrophage-colony-stimulating factor receptor (MCSFR) gene genotype chi-fms may be considered as one of the genetic predictors of BA. The homozygous genotype in a rare allele of the MCSFR gene may be also a predictor of BA.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

A familial survey was conducted in 81 probands who were diagnosed as having bronchial asthma (BA) and their 183 first-, second-, and third-degree relatives (a study group). A control group comprised 263 apparently healthy individuals. The familial accumulation of BA was ascertained in the families of probands with this condition. Autosomal dominant inheritance of BA was established. The heterozygous variant of the macrophage-colony-stimulating factor receptor (MCSFR) gene genotype chi-fms may be considered as one of the genetic predictors of BA. The homozygous genotype in a rare allele of the MCSFR gene may be also a predictor of BA.

Key concepts: Proband, Asthma, Genotype, Allele, Genetics, Medicine, Inheritance (genetic algorithm), Gene

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
[Clinical and genetic features in patients with asthma and their relatives]. — Research Paper | ScholarLens