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Precipitation of Acetaminophen in Supercritical Carbon Dioxide

최성우, Hwa Yong Kim, 오경실

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Abstract

Micronized acetaminophen was precipitated from ethanol solution using supercritical CO2 as antisolvent. A coaxial nozzle was used to introduce the supercritical CO2 and the acetaminophen/ethanol solution. The effects of pressure, temperature, CO2 flow rate and solvent flow rate were studied in the constant pressure and temperature condition. The particle size and morphology were influenced by the variations of precipitation condition. The particle size and morphology were analyzed with scanning electron microscopy.

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What this paper is about

Micronized acetaminophen was precipitated from ethanol solution using supercritical CO2 as antisolvent. A coaxial nozzle was used to introduce the supercritical CO2 and the acetaminophen/ethanol solution. The effects of pressure, temperature, CO2 flow rate and solvent flow rate were studied in the constant pressure and temperature condition. The particle size and morphology were influenced by the variations of precipitation condition. The particle size and morphology were analyzed with scanning electron microscopy.

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Available abstract

Micronized acetaminophen was precipitated from ethanol solution using supercritical CO2 as antisolvent. A coaxial nozzle was used to introduce the supercritical CO2 and the acetaminophen/ethanol solution. The effects of pressure, temperature, CO2 flow rate and solvent flow rate were studied in the constant pressure and temperature condition. The particle size and morphology were influenced by the variations of precipitation condition. The particle size and morphology were analyzed with scanning electron microscopy.

Key concepts: Supercritical fluid, Supercritical carbon dioxide, Particle size, Precipitation, Particle (ecology), Carbon dioxide, Materials science, Scanning electron microscope

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