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[Regulation of NF-kappa B activity].

Jakub Siednienko, Wojciech Gorczyca

Open publisher page 7 citations

Abstract

Nuclear factor kappa B (NF-kappa B) is common proinflammatory transcription factor involved in expression of c.a. 300 different genes. It is usually present in the cytosol as an inactive complex and upon activation translocates into the nucleus. The mechanisms of activation of NF-kappa B are complex and they involve several different signaling pathways and plethora of proteins. In this minireview we describe the main deciphered as well as suggested mechanisms regulating of NF-kappa B activity.

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What this paper is about

Nuclear factor kappa B (NF-kappa B) is common proinflammatory transcription factor involved in expression of c.a. 300 different genes. It is usually present in the cytosol as an inactive complex and upon activation translocates into the nucleus. The mechanisms of activation of NF-kappa B are complex and they involve several different signaling pathways and plethora of proteins. In this minireview we describe the main deciphered as well as suggested mechanisms regulating of NF-kappa B activity.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Nuclear factor kappa B (NF-kappa B) is common proinflammatory transcription factor involved in expression of c.a. 300 different genes. It is usually present in the cytosol as an inactive complex and upon activation translocates into the nucleus. The mechanisms of activation of NF-kappa B are complex and they involve several different signaling pathways and plethora of proteins. In this minireview we describe the main deciphered as well as suggested mechanisms regulating of NF-kappa B activity.

Key concepts: Transcription factor, NFKB1, Kappa, Cytosol, NF-κB, Proinflammatory cytokine, Cell biology, Nucleus

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