2011•PubMedRequires access

[The pathogenesis of primary immune thrombocytopenia].

Sif Gudbrandsdottir, Henrik Frederiksen, Henrik Birgens, Claus Henrik Nielsen, Ove Juul Nielsen, Jesper Stentoft, Hans Carl Hasselbalch

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Abstract

Primary immune thrombocytopenia (ITP)--formerly known as idiopathic thrombocytopenic purpura--is an autoimmune disorder characterized by immune-mediated thrombocytopenia. The aetiology of ITP remains unknown, but studies have shown that multiple immunological mechanisms are involved in the pathogenesis of ITP.This article aims to provide an overview of our knowledge of the pathogenesis of ITP.

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What this paper is about

Primary immune thrombocytopenia (ITP)--formerly known as idiopathic thrombocytopenic purpura--is an autoimmune disorder characterized by immune-mediated thrombocytopenia. The aetiology of ITP remains unknown, but studies have shown that multiple immunological mechanisms are involved in the pathogenesis of ITP.This article aims to provide an overview of our knowledge of the pathogenesis of ITP.

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Available abstract

Primary immune thrombocytopenia (ITP)--formerly known as idiopathic thrombocytopenic purpura--is an autoimmune disorder characterized by immune-mediated thrombocytopenia. The aetiology of ITP remains unknown, but studies have shown that multiple immunological mechanisms are involved in the pathogenesis of ITP.This article aims to provide an overview of our knowledge of the pathogenesis of ITP.

Key concepts: Pathogenesis, Immune thrombocytopenia, Thrombocytopenic purpura, Immunology, Immune system, Etiology, Medicine, Platelet

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[The pathogenesis of primary immune thrombocytopenia]. — Research Paper | ScholarLens