2004•Clinical EndoscopyRequires access
Esophageal Ulcer Induced by Alendronate
정용희, 장영운, 한주영, 이병욱, 한요셉, 동석호, Kim Hyo Jong, 김병호, 이정일, 장린
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Abstract
Alendronate sodium (Fosamax) is an aminophosphonate used in treatment of postmenopausal osteoporosis by inhibition of osteoclastic activity. Esophageal ulcers related to alendronate use have been reported at the rate of 2-6%. However, there have been no reports of esophagitis or esophageal ulcer by alendronate in Korea. We present a case of esophageal ulcer caused by alendronate. The patient presented with retrosternal pain and severe odynophagia for a few days. Esophagogastroduodenoscopy revealed multiple deep ulcers at the esophagus. Her symptoms resolved completely after stopping alendronate. A follow-up esophagogastroduodenoscopy 6 weeks later revealed complete healing of the ulcers.