2002•Obstetrics & Gynecology ScienceRequires access
When Can We Identify Fetal Male Gene By Using Maternal Plasma DNA
Soon Choul Hong, Jun S. Song, Soo Hun Cho, Jae Yoon Song, Seon Young Park, Young Tae Kim, Sun Haeng Kim, Kyu Wan Lee
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Abstract
Objective : To know when we can identify fetal Y chromosome SRY gene by using fetal DNA in maternal plasma. Methods : DNA from maternal plasma of 62 pregnant women (48: inpatients, 14: outpatients) underwent a sensitive Y-PCR assay to identify SRY gene of Y chromosome. Results : Of the patients, fetus-derived Y sequences were detected in 37 (88.1%) of the 42 maternal plasma samples from women bearing male fetuses. One of the 20 women bearing female fetuses had positive result from plasma DNA. Seventh gestational week was the earliest gestation of gender identification. Conclusion : We could identify fetal gender using fetal DNA in maternal plasma (sensitivity 88.1%). The earlist to detect was 7th gestational week.