2006•PubMedRequires access

[Bone and bone related biochemical examinations. Bone and collagen related metabolites. Tartrate-resistant acid phosphatase (TRACP)].

Yoshiko Mochizuki

Abstract

Tartrate-resistant acid phosphatase (TRACP) is a well-known marker for bone resorption, but it is not enough for clinical use in specificity of bone and instability in serum. Tartrate-resistant acid phosphatase type 5b (TRACP-5b) is an osteoclast-produced enzyme and was reported the clinical performance of a novel fragments absorbed immunocapture enzyme assay. TRACP-5b have smaller day-to-day and diurnal variation than those of urinary bone resorption markers and show the usefulness as promising markers in monitoring the treatment for osteoporosis.

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Key concepts: Tartrate-resistant acid phosphatase, Acid phosphatase, Bone resorption, Osteoclast, Chemistry, Bone remodeling, Resorption, Osteoporosis