1999•PubMedRequires access

[Study on the hepatic toxicity of cerous nitrate in rats].

Wenqi Yang, T Wang, H Lei, Yanting Yang

Abstract

Rats were injected with a single dose of cerous nitrate Ce (NO3)3 (150 mg/kg) intra-peritoneally and killed at 3, 6, 12, 24 and 48 hours later. The results showed that the concentrations of protein and malondialdehyde (MDA) in liver increased, but the concentration of glutathione (GSH) and the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione sulfatransferase (GSH-ST) decreased after Ce3+ administration. The results suggest that lipid peroxidation in liver may be an early consequence of Ce3+ exposure and the decrease of GSH might be considered as the cause of lipid peroxidation.

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Key concepts: Lipid peroxidation, Malondialdehyde, Glutathione, Superoxide dismutase, Glutathione peroxidase, Chemistry, Catalase, Toxicity