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The importance of human intestinal diamine oxidase in the oxidation of histamine and/or putrescine.

Tadeusz Biegański, Jürgen Kusche, Klaus Feussner, R. Hesterberg, Hans Richter, W Lorenz

Abstract

Histamine, naturally methylated histamine and putrescine are good substrates for human intestinal diamine oxidase, N-Methyl-N-formylhydrazine, the constituent of the mashroom poison-gyromitrin is an inhibitor of human intestinal diamine oxidase. Burimamide inhibits more effectively mammalian intestinal diamine oxidases than pea seedling diamine oxidase, beta-aminopropionitrile is a better inhibitor of pea seedling enzyme than mammalian diamine oxidases. This inhibitory differences might be related to preference in histamine or putrescine oxidizing activity of these enzymes.

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Key concepts: Diamine oxidase, Putrescine, Histamine, Amine oxidase (copper-containing), Diamine, Histamine N-methyltransferase, Biochemistry, Chemistry