1994•OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)Requires access
Exposure of F344 rats to aerosols of {sup 239}PuO{sub 2} and chronically inhaled cigarette smoke
G.L. Finch, K J Nikula, Edward B. Barr, William E. Bechtold, B.T. Chen, W. C. Griffith, CHARLES H. HOBBS, Hoover, J.L. Mauderly
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Abstract
Nuclear workers may be accidently exposed to radioactive materials such as {sup 239}PuO{sub 2} by inhalation, and thus have increased risk for lung cancer compared to the general population. Of additional concern is the possibility that interactions between radionuclides and other carcinogens may increase the risk of cancer induction. An important and common lung carcinogen is cigarette smoke. This study is being conducted to better determine the combined effects of inhaled {sup 239}PuO{sub 2} and cigarette smoke on the induction of lung cancer in rats.