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SIMULTANEOUS PASSIVE CUTANEOUS ANAPHYLAXIS AND ARTHUS REACTIONS IN MOUSE, RAT AND GUINEA-PIG.

L. Campbell Levy

Abstract

A technique for elicitation of simultaneous passive cutaneous anaphylaxis and reverse passive Arthus reactions in the same animal is described. Experimental evidence is presented to substantiate previous findings that these two skin reactions, inducible by the same BSA-rabbit anti-BSA system, are distinctive in several species. Dose—response data on Arthus and PCA reactions in the mouse, rat, and guinea-pig indicated that the mouse was least sensitive and guinea-pig most sensitive to these cutaneous reactions. Both types of cutaneous reactions were found to decrease in intensity as well as diameter in response to excess antigen in all three species.

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Key concepts: Arthus reaction, Guinea pig, Anaphylaxis, Skin reaction, Immunology, Animal species, Chemistry, Animal model