Modulation of biological tyrosine reactions by tyrosine phosphorylation.
Gmeiner Bm, Christian Seelos
Abstract
Gmeiner Bm, Christian Seelos
Abstract
This review focuses on the influence of tyrosine phosphorylation on the biological reactions of tyrosine. Reactions that are modulated by this amino acid modification include dityrosine formation, thyroid hormone synthesis, and DOPA formation. In addition, we show that the reactivity of tyrosine in the common Lowry method of determination of protein concentrations is lost upon phosphorylation of the amino acid.
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This review focuses on the influence of tyrosine phosphorylation on the biological reactions of tyrosine. Reactions that are modulated by this amino acid modification include dityrosine formation, thyroid hormone synthesis, and DOPA formation. In addition, we show that the reactivity of tyrosine in the common Lowry method of determination of protein concentrations is lost upon phosphorylation of the amino acid.
Key concepts: Tyrosine, Tyrosine phosphorylation, Phosphorylation, Medicine, Amino acid, Biochemistry, Protein tyrosine phosphatase, Protein phosphorylation