1987•PubMedRequires access
In vitro antibacterial activity of enoxacin, a new pyridonecarboxylic acid.
U Fabio, Moreno Bondi, Ferruccio Galletti, Gian Carlo Manicardi, Patrizia Messi, Rachele Giovanna Neglia, Chiara Casolari
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Abstract
The antibacterial activity of enoxacin was determined against 1015 strains of Gram-positive and Gram-negative bacteria, mainly freshly isolated from clinical specimens. The minimum inhibitory concentrations (MIC 50-75-90) were determined in comparison to three commonly used antibiotics: ampicillin, cefotaxime and gentamicin. Enoxacin has shown a broad spectrum of action and antibacterial activity in general higher that than of three currently available antibiotics. The antibacterial activity seems similar to that of other quinolones of second generation.