[Nitric oxide and cardiologic drugs].

The influence of simvastatin and metoprolol on nitric oxide synthesis (measured as NO metabolites plasma concentration) was studied. Results. It was revealed that both simvastatin and metoprolol diminish significantly plasma nitric oxide concentration by 24.6% and 23.7% respectively. It was also compared nitric oxide concentrations in plasma of rabbits, after 3 week of mononitrate isosorbitol and molsidomine administration--assuming that applied doses are relevant to maximal doses applied to the human. It was found that molsidomine releases more nitric oxide than mononitrate isosorbitol.