[Animal lipoxygenase: activation of reticulocyte lipoxygenase during interaction with natural and artificial membranes].

The rate of oxidation of exogenous arachidonate by homogenous samples of lipoxygenase from rabbit reticulocyte cytosol is significantly increased in the presence of various biological membranes (mitochondria, microsomes, erythrocyte ghosts, etc.). Unlike reticulocyte lipoxygenase, the rate of arachidonate oxidation by soybean lipoxygenase I in the presence of biomembranes is considerably reduced. The rate of arachidonate oxidation by reticulocyte lipoxygenase is also strongly increased in the presence of artificial membranes, e. g. liposomes from various phospholipids.