2012Natural Product CommunicationsOpen access

Antiproliferative Oleanane Saponins from Dizygotheca Elegantissima

Antonio Vassallo, Mariasabina Pesca, Letizia Ambrosio, Nicola Malafronte, Nadia Dekdouk Melle, Fabrizio Dal Piaz, Lorella Severino

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Abstract

Four new oleanane saponins (1-4), together with three known saponins, were isolated from the aerial parts of Dizygotheca elegantissima R. Vig. & Guillaumin. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all isolated compounds was evaluated.

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Four new oleanane saponins (1-4), together with three known saponins, were isolated from the aerial parts of Dizygotheca elegantissima R. Vig. & Guillaumin. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all isolated compounds was evaluated.

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Available abstract

Four new oleanane saponins (1-4), together with three known saponins, were isolated from the aerial parts of Dizygotheca elegantissima R. Vig. & Guillaumin. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all isolated compounds was evaluated.

Key concepts: Oleanane, Two-dimensional nuclear magnetic resonance spectroscopy, Chemistry, Heteronuclear single quantum coherence spectroscopy, Stereochemistry, Nuclear magnetic resonance spectroscopy, Saponin, Triterpene

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