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[Microdissection study of nephron growth during compensatory renal hypertrophy and postnatal ontogeny in rats].

Goncharevskaia Oa, Ruziev Tr

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Abstract

Unilateral nephrectomy stimulates renal growth with preservation of linear dependence between its mass and that of the body as it is observed in normally growing rats. Increase in the renal mass by 50% at compensatory hypertrophy is depended on a proportional growth of nephrons and their segments. In young rats during the period of the most intensive development (1--2 month of age) the renal weight increases by 100% and the length of nephron -- by 30%. The data obtained demonstrate that renal hypertrophy develops, mainly, at the expense of growth of the nephrons and their segments.

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What this paper is about

Unilateral nephrectomy stimulates renal growth with preservation of linear dependence between its mass and that of the body as it is observed in normally growing rats. Increase in the renal mass by 50% at compensatory hypertrophy is depended on a proportional growth of nephrons and their segments. In young rats during the period of the most intensive development (1--2 month of age) the renal weight increases by 100% and the length of nephron -- by 30%. The data obtained demonstrate that renal hypertrophy develops, mainly, at the expense of growth of the nephrons and their segments.

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Available abstract

Unilateral nephrectomy stimulates renal growth with preservation of linear dependence between its mass and that of the body as it is observed in normally growing rats. Increase in the renal mass by 50% at compensatory hypertrophy is depended on a proportional growth of nephrons and their segments. In young rats during the period of the most intensive development (1--2 month of age) the renal weight increases by 100% and the length of nephron -- by 30%. The data obtained demonstrate that renal hypertrophy develops, mainly, at the expense of growth of the nephrons and their segments.

Key concepts: Nephron, Renal mass, Microdissection, Compensatory hypertrophy, Muscle hypertrophy, Ontogeny, Compensatory growth (organ), Nephrectomy

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[Microdissection study of nephron growth during compensatory renal hypertrophy and postnatal ontogeny in rats]. — Research Paper | ScholarLens