[The relationship between the high inducibility genotype of CYP450IA1 and lung cancer susceptibility].

OBJECTIVE: To evaluate the role of polymorphism of CYP450IA1 gene in the susceptibility of lung cancer. METHODS: The polymorphism of CYP450IA1 gene in 149 lung cancer patients and 208 healthy controls were investigated by PCR technique. RESULTS: The high inducibility genotype (Val/Val type) of CYP450IA1 in lung cancer patients was 16.1%, which was significantly higher than that of controls, 8.7%. According to pathological classification of lung cancer, it was indicated that VAl/Val type in squamous carcinomas was the highest, 21.54%, which was significantly higher than that of controls (8.7%) and adenocarcinomas (8.00%). The Val/Val type in small cell carcinoma reached 17.6%. The relative risks were estimated according to smoking condition and CYP450IA1 genotype. Taking the risk of the category with non-smoking and non-high inducibility genotype (Val/ Val) to be at a baseline of 1.0, the odds ratio was 1.6 (P < 0.05) in non-smoking in non-smoking and Val/Val type 4.8 in smoking and Val/Val type (P < 0.001). The relative risk of Val/Val type was 2.2 times as non-Val/ Val type for smoking people. CONCLUSIONS: Development of lung cancer was associated with the high inducibility genotype of CYP450IA1. And Val/Val genotype of CYP450IA1 gene might be an important host hereditary marker for susceptibility to lung cancer.