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[Activity of endogenous anticoagulants (antithrombin III, protein C and protein S) in women after menopause treated with hormone replacement therapy (transdermal 17 beta-OH estradiol and oral medroxyprogesterone acetate)].

Rafał Ciepłuch, E Czestochowska

Abstract

The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma activities of antithrombin III, protein C and protein S before and after 6 and 12 months of HRT in 48 postmenopausal women. HRT consisted of transdermal estradiol and orally medroxyprogesterone acetate. We observed no statistically significant differences in plasma levels of the above endogenous anticoagulants before and during treatment.

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Available abstract

Key concepts: Medroxyprogesterone acetate, Medicine, Antithrombin, Transdermal, Menopause, Hormone replacement therapy (female-to-male), Medroxyprogesterone, Endogeny