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[A comparative assessment of heterogeneity of CD4 and CD8 lymphocyte subpopulations in newborns and adults by two-color flow cytometry].

Chernyshov Vp, I I Slukvin

Abstract

Majority of human newborn CD4+ lymphocytes were suppressor-inducer and had a CD45RA marker, the levels of CD4+Leu8- lymphocytes with helper function were markedly reduced in neonatal blood compared with that of normal adults. Decreased levels of CD8+ lymphocytes in neonate associated with low level of precursors and effectors of allocytotoxic T cells (CD8+CD11b-) and suppressor lymphocytes (CD8+CD11b+).

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Key concepts: Flow cytometry, CD8, Suppressor, Immunology, Lymphocyte, Biology, T lymphocyte, Effector