ScholarLens Back to search
1996•PubMedRequires access

[The relationship between p53 and PCNA in germ cell carcinoma].

X Zhang, Sen Hou, G Zhang

Open publisher page 0 citations

Abstract

To analyse the relationship between cellular proliferating status, p53 expressions and tumor biological characteristics, immunohistochemistry was used in 13 cases of testicular germ cell carcinoma paraffin section. The results show that PCNA-LI is higher significantly in invasive tumor group than in noninvasive group (P < 0.05). Although there were no significant differences of PCNA-LI, p53 between seminoma and nonseminoma, two parameters in the latter group were somewhat higher. There was a correlation of PCNA-LI with p53 in nonseminoma group (r = 0.64). It is concluded that PCNA-LI and p53 are both correlated positively with tumor differentiation.

About this research paper

What this paper is about

To analyse the relationship between cellular proliferating status, p53 expressions and tumor biological characteristics, immunohistochemistry was used in 13 cases of testicular germ cell carcinoma paraffin section. The results show that PCNA-LI is higher significantly in invasive tumor group than in noninvasive group (P < 0.05). Although there were no significant differences of PCNA-LI, p53 between seminoma and nonseminoma, two parameters in the latter group were somewhat higher. There was a correlation of PCNA-LI with p53 in nonseminoma group (r = 0.64). It is concluded that PCNA-LI and p53 are both correlated positively with tumor differentiation.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

To analyse the relationship between cellular proliferating status, p53 expressions and tumor biological characteristics, immunohistochemistry was used in 13 cases of testicular germ cell carcinoma paraffin section. The results show that PCNA-LI is higher significantly in invasive tumor group than in noninvasive group (P < 0.05). Although there were no significant differences of PCNA-LI, p53 between seminoma and nonseminoma, two parameters in the latter group were somewhat higher. There was a correlation of PCNA-LI with p53 in nonseminoma group (r = 0.64). It is concluded that PCNA-LI and p53 are both correlated positively with tumor differentiation.

Key concepts: Proliferating cell nuclear antigen, Seminoma, Immunohistochemistry, Medicine, Germ cell, Pathology, Carcinoma, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
[The relationship between p53 and PCNA in germ cell carcinoma]. — Research Paper | ScholarLens