Disulfiram-Ethanol Reaction to Implanted Disulfiram

It is postulated that a recent suggestion that the disulfiram implant technique is not pharmacologically effective may be premature. Some literature is cited in support of this contention, and three case histories of disulfiram implant patients who experienced disulfiram-ethanol reactions when they recommenced drinking are reported. It is suggested that the disulfiram-ethanol reactions to implanted disulfiram may be delayed in onset and of longer duration than those obtained from orally-administered disulfiram. Possible mechanisms are discussed.