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1981•Canadian Journal of Neurological Sciences / Journal Canadien des Sciences NeurologiquesOpen access

Valproic Acid and Plasma Levels of Primidone and Derived Phenobarbital

Joseph Bruni

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Abstract

Five patients were studied to determine whether kinetic interaction occurs between valproic acid and primidone. During concurrent administration of primidone and valproic acid no significant interaction was observed. Primidone and derived phenobarbital levels did not change significantly. No adjustment of primidone dose was required when valproic acid was used as adjunctive therapy.

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What this paper is about

Five patients were studied to determine whether kinetic interaction occurs between valproic acid and primidone. During concurrent administration of primidone and valproic acid no significant interaction was observed. Primidone and derived phenobarbital levels did not change significantly. No adjustment of primidone dose was required when valproic acid was used as adjunctive therapy.

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Available abstract

Five patients were studied to determine whether kinetic interaction occurs between valproic acid and primidone. During concurrent administration of primidone and valproic acid no significant interaction was observed. Primidone and derived phenobarbital levels did not change significantly. No adjustment of primidone dose was required when valproic acid was used as adjunctive therapy.

Key concepts: Primidone, Valproic Acid, Phenobarbital, Carbamazepine, Pharmacology, Epilepsy, Anticonvulsant, Medicine

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