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Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine.

Tina Colombo, Cosmo Rossi, Maurizio D’Incalci

Abstract

In this study we show that cytarabine given simultaneously with 5-aza-2'-deoxycytidine (Aza-dC) antagonized Aza-dC activity against L1210 mouse leukemia. This antagonism was seen after a single dose (on Day 3 or Day 5 after tumor implant) and after repeated doses. This observation suggests caution in combining cytarabine with Aza-dC in the treatment of human leukemias.

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Key concepts: Cytarabine, Deoxycytidine, Antagonism, Medicine, Concomitant, Pharmacology, Leukemia, Deoxycytidine kinase