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The role of some prostaglandins in the interaction of fibrinogen degradation products (FDP) with central dopamine receptors of rats.

W Buczko, K Wiśniewski

Abstract

Indomethacin and fibrinogen degradation products (FDP) augmented amphetamine and apomorphine-induced stereotypies. In contrast, PGE1 and PGE2 decreased the stereotypies in rats, while PGF2 alpha enhanced amphetamine-induced stereotypy. Indomethacin given in combination with the peptides did not change their effect, whereas prostaglandins diminished the stimulatory effect of FDP on the amphetamine or apomorphine-induced stereotypy. Indomethacin and studied prostaglandins did not influence inhibitory action of FDP on haloperidol-induced catalepsy. It is concluded that prostaglandins do not play any essential role in the interaction of FDP with dopaminergic system in the CNS.

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Key concepts: Stereotypy, Apomorphine, Amphetamine, Catalepsy, Chemistry, Haloperidol, Dopaminergic, Methysergide