2014•PubMedRequires access

Effect of artificial musk aqueous extract on the expressions of inflammatory mediators released from lipopolysaccharide-stimulated RAW264.7 cells.

Yu Meng, Qin-Wen Zou, Jinye Bai, Gui-Fang Cheng, Xuan Xiao, Shu Zhang, Xiu-Yuan Zhu, Xiaoliang Wang

Abstract

OBJECTIVE: To identify the anti-inflammatory effects of artificial musk aqueous extract(AME)on lipopolysaccharide-stimulated cytokines secreted or released by RAW264.7 cells. METHODS: Cytokines including interleukin(IL)-6,IL-10,and tumor necrosis factor Α were determined using cytokine enzyme-linked immunosorbent assay kits. RESULT: Compared with model group,the levels of major cytokines such as tumor necrosis factor Α,IL-6,and IL-10 significantly decreased in different AME groups in a dose-dependent manner. CONCLUSION: In lipopolysaccharide-stimulated RAW264.7 macrophages,AME can remarkably inhibit the release of inflammatory cytokines and thus exerts its anti-inflammatory effects.

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Key concepts: Lipopolysaccharide, Tumor necrosis factor alpha, Cytokine, Proinflammatory cytokine, Interleukin, Tumor necrosis factor α, Chemistry, Pharmacology