Spontaneous Remission of Nephrotic Syndrome in IgA Nephropathy

Although a moderate degree of proteinuria is common in patients with IgA nephropathy (IgAN), ne- phrotic syndrome combined with IgAN is rare. It has been reported that approximately 5% of all pa- tients with IgAN are complicated by minimal change disease and these patients respond well to corti- costeroid therapy. However, spontaneous remission is uncommon in heavy proteinuric patients with IgAN. Recently, we experienced two cases of spontaneous remission of nephrotic syndrome combined with IgAN without use of corticosteroid. In these patients, heavy proteinuria disappeared in 1 month after the onset and no recurrence occurred during follow-up. With such limited number of cases, factors associated with spontaneous remission in these patients could not be explored. Further study with a larger number of patients is required and careful attention should be paid to these complicated cases.