2014PubMedRequires access

[Sumatriptan plus naproxen for acute migraine attacks in adults].

Henrik Winther Schytz, Lars Bendtsen

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Abstract

It is of great importance to improve acute treatment of migraine attacks. Non-steroidal anti-inflammatory drugs (NSAID) and triptans have different anti-nociceptive effects, so a combination of these could theoretically lead to more effective acute migraine treatment. A recent meta-analysis investigated the combined effect of sumatriptan and naproxen and found it to be more effective than sumatriptan alone. However, the number needed to treat was high. Combined sumatriptan/naproxen should be reserved to those without efficient response to triptans.

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What this paper is about

It is of great importance to improve acute treatment of migraine attacks. Non-steroidal anti-inflammatory drugs (NSAID) and triptans have different anti-nociceptive effects, so a combination of these could theoretically lead to more effective acute migraine treatment. A recent meta-analysis investigated the combined effect of sumatriptan and naproxen and found it to be more effective than sumatriptan alone. However, the number needed to treat was high. Combined sumatriptan/naproxen should be reserved to those without efficient response to triptans.

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Available abstract

It is of great importance to improve acute treatment of migraine attacks. Non-steroidal anti-inflammatory drugs (NSAID) and triptans have different anti-nociceptive effects, so a combination of these could theoretically lead to more effective acute migraine treatment. A recent meta-analysis investigated the combined effect of sumatriptan and naproxen and found it to be more effective than sumatriptan alone. However, the number needed to treat was high. Combined sumatriptan/naproxen should be reserved to those without efficient response to triptans.

Key concepts: Triptans, Sumatriptan, Naproxen, Migraine, Medicine, Acute migraine, Rizatriptan, Naproxen Sodium

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