2011•International Journal of Immunopathology and PharmacologyRequires access
Allergic Inflammation: Role of Cytokines with Special Emphasis on IL-4
Andrea Saggini, Giulio Maccauro, Domenico Tripodi, M.A. De Lutiis, Francesca Conti, Paolo Felaco, Mario Fulcheri, Renato Galzio, A. Caraffa, P. Antinolfi, Mario Felaco, Fernanda Cláudia Pandolfi, G. Sabatino, Giampiero Neri, Y.B. Shaik-Dasthagirisaheb
Open publisher page 37 citations
Abstract
This review examines recent articles on the relationship of cytokines to allergy and inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is therefore to review published studies to identify cytokines consistently involved in allergic inflammation. Proinflammatory cytokines, including IL-4, IL-5, IL-13 and GM-CSF along with TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 and IFN-gamma are deeply involved in the regulation of asthma. Blocking the effect of these proinflammatory cytokines might provide new therapeutic approaches for the control of allergy and inflammation.