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[Heat shock protein 70 expression following transient ischemia in the gerbil].

Gu Wp, Yang Qd, Xie Gj

Abstract

OBJECTIVE: To study the expression of heat shock protein 70(HSP70) following transient ischemia in the gerbil. METHODS: Immunohistochemistry(IHC) was used to determine the expression of the HSP70 protein in the forebrain during different periods after post-ischemic reperfusion in the gerbil, and the neuronal damage was examined with microscope. RESULTS: The HSP70 protein was only expressed at the 1st day of reperfusion(P < 0.01); and most of the neurons showed damage on the 7th day of reperfusion; heat-preconditioning could increase the expression of HSP70 protein(P < 0.01) and decrease the neuronal damage(P < 0.001) after 6 min of ischemia. CONCLUSION: Heat-preconditioning could protect neural cells from damage by increasing the expression of the HSP70 protein.

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Key concepts: Gerbil, Hsp70, Heat shock protein, Ischemia, Immunohistochemistry, Forebrain, Protein expression, Medicine