1979•PubMedRequires access
Des 4-trans-hydroxy-glibenclamide show hypoglycemic activity?
L Balant, J Fabré, L Loutan, Hilda Samimi
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Abstract
Different doses of glibenclamide and of 4-transhydroxy-glibenclamide (main metabolite in man) were administered i.p. to rats and blood glucose was measured. The comparison of the doses capable of producing a 30% decrease of the glycemia shows that 4-trans-hydroxy-glibenclamide is about 6.5 times less potent than glibenclamide in our experimental conditions.