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1970•Australasian Annals of MedicineRequires access

Measurement of Glomerular Filtration Rate using a Single Injection of 51Cr‐Edetic Acid

Ross R. Bailey, T. G. H. Rogers, James Tait

Open publisher page 19 citations

Abstract

Summary A simple method of estimating the glomerular filtration rate using a single injection of 51 Cr‐EDTA is described. The technique, which avoids urine collections, has been found to correlate well with the 24 hour endogenous creatinine clearance over a wide range of renal function. The complex is not attached to erythrocytes or significantly bound to plasma proteins. In non‐oedematous patients equilibration in the body space is completed in under 2 hours, following which an exponential fall in plasma activity occurs.

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Summary A simple method of estimating the glomerular filtration rate using a single injection of 51 Cr‐EDTA is described. The technique, which avoids urine collections, has been found to correlate well with the 24 hour endogenous creatinine clearance over a wide range of renal function. The complex is not attached to erythrocytes or significantly bound to plasma proteins. In non‐oedematous patients equilibration in the body space is completed in under 2 hours, following which an exponential fall in plasma activity occurs.

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Available abstract

Summary A simple method of estimating the glomerular filtration rate using a single injection of 51 Cr‐EDTA is described. The technique, which avoids urine collections, has been found to correlate well with the 24 hour endogenous creatinine clearance over a wide range of renal function. The complex is not attached to erythrocytes or significantly bound to plasma proteins. In non‐oedematous patients equilibration in the body space is completed in under 2 hours, following which an exponential fall in plasma activity occurs.

Key concepts: Renal function, Urine, Chemistry, Clearance, Creatinine, Filtration (mathematics), Urine collection device, Chromatography

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