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5-Aminosalicylic acid in patients with ulcerative colitis in remission: plasma levels after administration of a new rectal enema.
Paolo Gionchetti, Andrea Belluzzi, Massimo Campieri, F. Torresan, Tabanelli Gm, C. Brignola, M. Miglioli, L Barbara
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Abstract
Plasma levels of total 5-aminosalicylic acid (5-ASA) were determined after a single administration of 2 g and 4 g 5-ASA enemas to 6 patients with ulcerative colitis. The mean plasma levels and AUC values confirmed that the active substance is poorly absorbed by rectal route.