1975•PubMedRequires access
The effect of cancer chemotherapy on lysosomal enzymic activities (acid phosphatase) of Ehrlich ascites carcinoma cells.
Cornelia Todorutiu, Doina Daicoviciu
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Abstract
The distribution of acid phosphatase in Ehrlich ascites carcinoma cells was studied by histochemical techniques in mice treated with antitumoral agents (Tio-Tepa, Cosmegen). The results proved the accuracy of the histoenzymatic demonstration of APh activity for the study of early changes induced in Ehrlich ascites tumor by antitumoral drugs : these changes precede those revealed by routine histological methods and are related to the degree of sensitivity of the tumor to the drugs.