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[Cholecystokinin receptors. A target for tomorrow's psychopharmaceuticals?].

Olof Zachrisson, Nils Lindefors

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Abstract

The neuropeptide cholecystokinin (CCK) and its receptors are highly expressed in brain regions important for cognitive functions, emotions and the initiation of movements. Two high-affinity receptors exist for CCK, the A-and B-type. A number of ligands are developed for these receptors. Evidence for the involvement of CCK and its receptors in the pathofysiology of neuropsychiatric disorders is discussed. In addition, we discuss the possible use of CCK receptors ligands in the treatment of such disorders.

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What this paper is about

The neuropeptide cholecystokinin (CCK) and its receptors are highly expressed in brain regions important for cognitive functions, emotions and the initiation of movements. Two high-affinity receptors exist for CCK, the A-and B-type. A number of ligands are developed for these receptors. Evidence for the involvement of CCK and its receptors in the pathofysiology of neuropsychiatric disorders is discussed. In addition, we discuss the possible use of CCK receptors ligands in the treatment of such disorders.

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Available abstract

The neuropeptide cholecystokinin (CCK) and its receptors are highly expressed in brain regions important for cognitive functions, emotions and the initiation of movements. Two high-affinity receptors exist for CCK, the A-and B-type. A number of ligands are developed for these receptors. Evidence for the involvement of CCK and its receptors in the pathofysiology of neuropsychiatric disorders is discussed. In addition, we discuss the possible use of CCK receptors ligands in the treatment of such disorders.

Key concepts: Cholecystokinin, Receptor, Cholecystokinin receptor, Neuropeptide, Neuroscience, Class C GPCR, G protein-coupled receptor, Chemistry

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