Expression and clinical significance of Anti-C1q antibodies in sera of patients with Lupus nephritis

Objective:To explore the expression of anti-C1q antibodies and clinical significance in patients with lupus nephritis(LN).Methods:ELISA assay was performed to examine anti-C1q antibodies in the sera of 46 patients with LN and 31 patients of systemic lupus erythematosus without renal damage.Standard methods were used for laboratory testing.Results:Anti-C1q antibodies were sianificantly higher in LN than in controls(P0.01).The positive rate of anti-C1q antibodies was significantly higher in LN than in controls.There was significant and positive correlation anti-C1q antibodies and SLEDAI score in LN(P0.01).Conclusion:In patients with LN,anti-C1qantibodies were significantly higher than control groups.And anti-C1q antibodies was suggested to play a crucial role in the patients of LN.Anti-C1q antibodies had potential utility as a diagnostic tool and disease activity marker.