ScholarLens Back to search
2011•China Animal Husbandry & Veterinary MedicineRequires access

The Role of chTLR4 and its Signaling Pathway in Chicken with LPS-induced Lymphocytes

Zhenguo Yang

Open publisher page 0 citations

Abstract

Toll-like receptor 4 is the transmembrane receptor of lipopolysaccharides(LPS),it mediates a variety of injury response induced by LPS.The experiments on chicken lymphocytes induced by LPS with 6,12,24,48 h,to show IL-1β,NF-κB levels,as in-depth study of intracellular TLR4-mediated LPS signaling basis.The results showed that LPS induced cells,IL-1β,NF-κB content increased,both reached the maximum at 24 h,and then began to decreased.The groups in 12,24 h were significantly higher than the control groups(P0.05),the groups in 6,48 h groups were not significantly higher than the control groups(P0.05).

About this research paper

What this paper is about

Toll-like receptor 4 is the transmembrane receptor of lipopolysaccharides(LPS),it mediates a variety of injury response induced by LPS.The experiments on chicken lymphocytes induced by LPS with 6,12,24,48 h,to show IL-1β,NF-κB levels,as in-depth study of intracellular TLR4-mediated LPS signaling basis.The results showed that LPS induced cells,IL-1β,NF-κB content increased,both reached the maximum at 24 h,and then began to decreased.The groups in 12,24 h were significantly higher than the control groups(P0.05),the groups in 6,48 h groups were not significantly higher than the control groups(P0.05).

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Toll-like receptor 4 is the transmembrane receptor of lipopolysaccharides(LPS),it mediates a variety of injury response induced by LPS.The experiments on chicken lymphocytes induced by LPS with 6,12,24,48 h,to show IL-1β,NF-κB levels,as in-depth study of intracellular TLR4-mediated LPS signaling basis.The results showed that LPS induced cells,IL-1β,NF-κB content increased,both reached the maximum at 24 h,and then began to decreased.The groups in 12,24 h were significantly higher than the control groups(P0.05),the groups in 6,48 h groups were not significantly higher than the control groups(P0.05).

Key concepts: TLR4, Receptor, Intracellular, Lipopolysaccharide, Signal transduction, Transmembrane protein, Toll-like receptor, Chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Role of chTLR4 and its Signaling Pathway in Chicken with LPS-induced Lymphocytes — Research Paper | ScholarLens