The effect of Dexmedetomidine on recovery of general anesthesia in children

【Objective】 To observe the effect of Dexmedetomidine on recovery of general anesthesia in children.【Methods】 60 children of ASA(I-II) were scheduled to routine inguinal hernia during general anesthesia.They were randomly divided to two groups: The control group(C n =30) and the Dexmedetomidine group(D n =30).The patients of group C were intravenously infused normal saline 10 ml and the patients of group D were intravenously infused Dexmedetomidine 0.5μg/kg.All patients were intravenous induction by remifentanil 0.5μg/kg and propofol 2 mg/kg.Anesthesia was maintained with intravenous infusion of propofol 5 mg·kg·h and remifentanil 0.2 μg/kg·min.All patients were intravenous infused fentanil 0.1μg/kg at 15 minutes before the end of surgery.Heart rate(HR) plus oxygen saturatio(SpO2) n were observed and recorded at wake-up after anesthesia(T0),10 min after wake-up(T1),30 min after wake-up(T2),60 min after wake-up(T3).Wake-up time,the cases of emergence agitation,the score of emergence agitation were observed and recorded.【Results】 There was no difference on SpO2 in two groups of children.The HR in group D was significantly lower than that in group C.The wake-up time in group D was significantly longer than that in group C.The cases of emergence agitation and the score of emergence agitation were significantly lower than that in group C(P 0.05).【Conclusion】 Preoperative intravenous Dexmedetomidine 0.5 μg/kg could effectively prevent emergence agitation after general anesthesia in children and have no respiratory depression and in preventing emergence agitation after general anesthesia is a good choice.