Effect of Ulinastatin on Perioperative Stage Cytokine and Liver Function in Patients Undergoing Hepatectomy

Objective To investigate the effects of ulinastatin on cytokine and liver function parameters in patients underwent hepatectomy. Methods Twenty-eight primary hepatic carcinoma scheduled for hepatectomy were divided into two groups, each group consisted 14 patients: the controlled group(group C)and ulinastatin group (group W). In group W, patient received ulinastatin 10000U.kg-1,Plasma levels of alanine transaminase(ALT), aspartate transaminase(AST), total bilirubin(TBIL), TNF-ɑ, and IL-6 were measured before operation(T_1), 10min after hepatic inflow occlusion(T_2), 20min after recovering hepatic inflow(T_3), 1h after recovering hepatic inflow(T_4), 24h (T_5), 3-day (T_6) after operation. Results In the T_2,T_3,T_4,T_5,T_6 time points, the plasma levels of ALT, AST, TBIL were lower in the W group than that in the C group. The plasma levels of ALT, AST in the T_3, T_4, T_5 time points in the W group was significantly lower than that in the C group(P0.05). On the first postoperative day, the plasma levels of TBIL in the W group was significantly lower than that in the C group(P0.05). TNF-ɑ﹑IL-6 in the T_3, T_4, T_5 time points in the W group was significantly lower than that in the C group(P0.05). Conclusions The results suggest that ulinastatin can effectively holdback the release of cytokine and protect liver function in patients underwent hepatectomy.