2007•Zhonghua neifenmi daixie zazhiRequires access

Smoking inhibits expressions of insulin receptor substrate-1 mRNA and protein in rat muscle

Ren We

Abstract

Insulin receptor substance-1 (IRS-1) mRNA and protein were assayed in rat muscle of hindlamb by RT-PCR and immunohistochemistry respectively.Smoking decreased the expressions of IRS-1 mRNA and protein in rat muscle of normal chow smoking group,high fat chow smoking group and diabetic smoking group as compared with matched control groups (P0.05 or P0.01),suggesting that smoking appears to be one of the molecular mechanisms leading to insulin resistance.

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Key concepts: Internal medicine, Endocrinology, Messenger RNA, Insulin resistance, Immunohistochemistry, Receptor, Insulin receptor, Insulin