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2006•Zhongguo yaofangRequires access

Pharmacokinetics of Indapamide by Oral in Human Body

LI Zuoji

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Abstract

OBJECTIVE:To establish a method for the determination of serum indapamide concentration.METHOD:10healthy male volunteers were assigned to receive7.5mg indapamide capsule on empty stomach with time-concentration deˉtermined by HPLC,and the pharmacokinetics parameters were accounted.RESULTS:C max was(0.212±0.167)mg/L,t max was(2.14±0.59)h,t 1/2 was(19.69±0.75)h,AUC 0～72 was(3.636±0.503)(mg·L)/h and AUC 0～∝ was(3.937±0.518)(mg·L)/h.CONCLUSION:The established method can be used for the clinical analysis on the use of indapamide and its pharmacokinetics study.

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What this paper is about

OBJECTIVE:To establish a method for the determination of serum indapamide concentration.METHOD:10healthy male volunteers were assigned to receive7.5mg indapamide capsule on empty stomach with time-concentration deˉtermined by HPLC,and the pharmacokinetics parameters were accounted.RESULTS:C max was(0.212±0.167)mg/L,t max was(2.14±0.59)h,t 1/2 was(19.69±0.75)h,AUC 0～72 was(3.636±0.503)(mg·L)/h and AUC 0～∝ was(3.937±0.518)(mg·L)/h.CONCLUSION:The established method can be used for the clinical analysis on the use of indapamide and its pharmacokinetics study.

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Available abstract

OBJECTIVE:To establish a method for the determination of serum indapamide concentration.METHOD:10healthy male volunteers were assigned to receive7.5mg indapamide capsule on empty stomach with time-concentration deˉtermined by HPLC,and the pharmacokinetics parameters were accounted.RESULTS:C max was(0.212±0.167)mg/L,t max was(2.14±0.59)h,t 1/2 was(19.69±0.75)h,AUC 0～72 was(3.636±0.503)(mg·L)/h and AUC 0～∝ was(3.937±0.518)(mg·L)/h.CONCLUSION:The established method can be used for the clinical analysis on the use of indapamide and its pharmacokinetics study.

Key concepts: Indapamide, Pharmacokinetics, Capsule, Chromatography, Pharmacology, Chemistry, Medicine, Diuretic

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