Expression of basic fibroblast growth factor in the brain of epileptic rat induced with pentetrazole

Objective To study the expression of basic fibroblast growth factor(bFGF) in the hippocampus of epileptic pedo-rats at different time points and investigate its bearing on epilepsy.Methods Forty-two 14-day old SD pedo-rats were randomly divided into two groups: A(epilepsy model group) and B(normal saline group).Pentetrazole was used to induce seizure models.The expression of bFGF in the hippocampus of rats was studied by immunofluorescent labeling technique.H-E staining was done for pathomorphological study.Results In group A,neuronal degeneration and necrosis in the hippocampus,and cellular proliferation of glial cells as well,were noticed;the expression of bFGF was increased,most marked 1 day after seizure(P0.01),continued to be higher for 7 days(P0.05),and then declined and approached the control level 14 days later(P0.05).Conclusion The expression of bFGF in hippocampus of 14-day rat is increased after acute epilepsy,significantly higher for 7 days after seizure.bFGF may play an important role in the self-plerosis after brain injury induced by epilepsy in pedo-rats.