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2006•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access

Relation between polymorphism of angiotensin-converting enzyme gene and liver cirrhosis

Xiao Fan

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Abstract

[Objective] To study the relationship between the development of liver cirrhosis and the genotype of ACE.[Methods] 193 cases of patients with liver cirrhosis and 219 cases of control were selected and were determined genotype of ACE by polymerase chain reaction(PCR).[Result] Among the control group,Genotype DD,II and DI were respectively 21.0%,29.2% and 49.8%;while among the patients with liver cirrhosis,they were 15.5%,38.3% and 46.1%.There was no significant difference in genotype distribution between the two groups.I allele frequencies in patients with liver cirrhosis were more than that of the control.[Conclusion] I allele site is prone to develop liver cirrhosis.

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What this paper is about

[Objective] To study the relationship between the development of liver cirrhosis and the genotype of ACE.[Methods] 193 cases of patients with liver cirrhosis and 219 cases of control were selected and were determined genotype of ACE by polymerase chain reaction(PCR).[Result] Among the control group,Genotype DD,II and DI were respectively 21.0%,29.2% and 49.8%;while among the patients with liver cirrhosis,they were 15.5%,38.3% and 46.1%.There was no significant difference in genotype distribution between the two groups.I allele frequencies in patients with liver cirrhosis were more than that of the control.[Conclusion] I allele site is prone to develop liver cirrhosis.

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Available abstract

[Objective] To study the relationship between the development of liver cirrhosis and the genotype of ACE.[Methods] 193 cases of patients with liver cirrhosis and 219 cases of control were selected and were determined genotype of ACE by polymerase chain reaction(PCR).[Result] Among the control group,Genotype DD,II and DI were respectively 21.0%,29.2% and 49.8%;while among the patients with liver cirrhosis,they were 15.5%,38.3% and 46.1%.There was no significant difference in genotype distribution between the two groups.I allele frequencies in patients with liver cirrhosis were more than that of the control.[Conclusion] I allele site is prone to develop liver cirrhosis.

Key concepts: Cirrhosis, Genotype, Allele, Internal medicine, Gastroenterology, Angiotensin-converting enzyme, Polymerase chain reaction, Liver enzyme

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